The world of education will never be separated from the diversity of students. This diversity is based on student characteristics. Differentiated Instruction is a learning strategy that meets all students' needs. This research aimed to describe the implementation of differentiated instruction in teaching English. A qualitative case study method was used by the researcher in this study. In addition, this research used data collection techniques such as observations, interviews, and documentation. Furthermore, the data analysis techniques were data reduction, data display, and conclusion drawing. The subjects of the research were an English teacher and 7th grade students at MTs Ma’arif NU 1 Cilongok, Banyumas. The research result found that MTs Ma’arif NU 1 Cilongok was chosen as the pilot school for the first school in junior high school level in Cilongok sub-district that implemented the differentiated instruction. The English teacher at the 7th grade implemented the differentiated instruction based on the students’ readiness, instead of based on the learning style as the other school.